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| Articles by Calder Qimat |
81. PLX4720 - REGARDING ITS WIDESPREAD THERAPEUTIC APPLICATION
December 19, 2011
INTRODUCTION
Out of the three different splice variants of RAF, mutations within the B-Raf oncogene result into a missense mutation within the BRAF kinase. This mutation is commonly seen in many kinds of cancers. The cancer cells harboring this mutation become resistant to various chemothera...
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82. Agents for treatment of asthma and masitinib
December 18, 2011
The current situation of asthma
There are a large proportion of asthmatic patient in the world. As we known, asthmatic can be satisfactorily treated by combining anti-inflammatory drugs and bronchodilators. Asthma is a chronic inflammatory condition, with bronchial recruitment, activation of...
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83. Akt in neointimal hyperplasia development
December 18, 2011
How to confirm the role of akt in the signaling pathway by experiment results? It’s a question for many researchers and I hope I can introduce a way to solve the problem today. I would give an example to explain to way to prove our hypothesis.
Assuming that we got a compound which can inhibi...
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84. bcr-abl kinase inhibitors
December 16, 2011
Mechanisms resulting in imatinib-resistance can be subdivided into bcr-abl dependent and bcr-ab independent mechanisms. Bcr-abl dependent mechanisms include bcr-abl duplication and mutation. Bcr-abl duplication was the first mechanism of imatinib-resistance to be described. Gene duplication results ...
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85. PARP inhibitors
December 16, 2011
PF-2341066, Sunitinib, Temsirolimus, Vorinostat, |
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86. Tyrosine kinase inhibitors
December 16, 2011
PLX-4032, Vemurafenib, Zelboraf, Crizotinib, |
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87. Treatment of late stage metastatic NSCLC
December 16, 2011
INTRODUCTION
Lung cancer is the number one cause of cancer-related death worldwide. The two classes of lung cancer are small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). The most common forms of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcin...
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88. The Met tyrosine kinase is one of the most dysregulated pathways in many cancers
December 15, 2011
INTRODUCTION
Mesenchymal-epithelial transition (Met) tyrosine kinase is the receptor for hepatocyte growth factor (HGF), which is normally active in wound healing, liver regeneration, and embryonic development. However, the Met pathway is one of the most frequently dysregulated pathways in h...
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89. Met Inhibitors Research
December 15, 2011
Compound Libraries, compound library, High Throughput Screening, Screening Libraries, |
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90. Met Inhibitors
December 15, 2011
INTRODUCTION
Mesenchymal-epithelial transition (Met) tyrosine kinase is the receptor for hepatocyte growth factor (HGF), which is normally active in wound healing, liver regeneration, and embryonic development. However, the Met pathway is one of the most frequently dysregulated pathways in h...
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Author: Calder Qimat
