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| Articles by Calder Qimat |
41. GIVINOSTAT FIGHTS AGAINST CANCER, Vorinostat, Belinostat
February 02, 2012
Givinostat is a derivative of hydroxamic acid and is within the early phases of clinical development. Large scale research has shown that the primary causes behind cancer are genetic mutations and epigenetic modifications. It is very difficult to correct the gene mutations whereas epigenetic modific...
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42. Predictors of dasatinib response for clinical evaluation
January 19, 2012
Patient selection has always been a laudable goal of targeted therapy and early successes, such as trastuzumab for the treatment of human epidermal growth factor receptor 2–positive breast cancer and imatinib for c-KIT–expressing gastrointestinal stromal tumors, fostered the concept of tailored ther...
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43. AR-42 AND CHRONIC LYMPHOCYTIC LEUKEMIA
January 19, 2012
R935788, r788, BIBW2992 & more.">INTRODUCTION
Histone deacetylases is the name given to the enzymes responsible of catalyzing the removal of acety...
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44. Sorafenib is promising to induce apoptosis of cancerous cells
January 19, 2012
INTRODUCTION
Two vital pathways are stimulated via RTK or receptor tyrosine kinase. These pathways include the PI3K which is progressed through AKT and secondly mitogen activated protein (MAP) kinase pathway which depends on ERK1/2 for its progress. MAP kinase pathway is very important for t...
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45. Exelixis.Inc describe the inhibitor as a potent inhibitor of MET and VEGFR2
January 18, 2012
Exelixis.Inc is a great drug discovery company and invented a list of inhibitors including 880, 147, 765, 518, 652/ 014, 139, 281, 475, 550 and Cabozantinib ( 184). Some inhibitors have already been used in our experiments and some inhibitors is still unknown. It’s still difficult for us to...
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46. The process of apoptosis is a target for compounds in chemical libraries
January 18, 2012
Introduction
It is the beauty of nature that it keeps a check on each and every reaction taking place within us. There is a discipline not only in the creation of newer entities but there is also decency in the destruction of older ones when not required. The programmed destruction of cells ...
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47. MGCD0103 stimulates the death of cancerous cells and inhibits proliferation
January 18, 2012
INTRODUCTION
The epigenetic mechanism is involved in the transcription of different genes along with a vital role of HDACs (histone deacetylases). Histones proteins are attached with the DNA in the nucleus and are deacetylated as the acetyl group is dissociated from Lysine residues present i...
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48. EFFECTS OF PD0325901 ON PTC
January 18, 2012
INTRODUCTION
Various mutations are mainly the cause cancer or tumor growth. A good number of pathways have been studied so far in order understand the mechanism of cancer growth and proliferation. Among these pathways the most important one is the Ras originated and to downstream Raf-MEK1/ME...
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49. Analysis of cervical cancer with pi3k
January 16, 2012
In this poster, I would introduce a new article published in cancer research and I wanna to recommend a way to discovery the relationship between gene expression and cancer in vivo. Researchers in this article just gave an example and we could do more study in similar way in future.
The art...
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50. Systematic study of targets is crucial to design target-oriented compound libraries
January 16, 2012
Introduction
Presently a wide range of approaches are available for the high throughput screening of compound libraries. Broadly the screening may be target oriented or diversity oriented screening. The high cost of screening whit lesser chances of successful hits is the main bottleneck in e...
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Author: Calder Qimat
