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| Articles by Calder Qimat |
31. GDC-0879 and Treatment
February 09, 2012
There are various reasons of cancer formation but most of cancers are associated with mutated MAP kinase pathway. GDC-0879 is among such inhibitors which can inhibit this mutated kinases pathway. This important pathway initiates from RAS and leads to the other downstream kinases including Raf, MEK a...
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32. Nilotinib is the first generation drug for the treatment of cancer
February 08, 2012
Imatinib, Nilotinib, Paclitaxel and to help them make more significant discoveries.">Nilotinib (AMN107) is a tyrosine kinase inhibitor used for the treatment ...
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33. Tipifarnib and MAPK pathway
February 08, 2012
The rate of pancreatic cancer has increased to a large extent. Almost 90 % of cases have a K-ras mutation in them and hence express Ras oncoprotein constitutively. It is normally treated by radiochemotherapy. To reduce metastasis gemcitabine based treatment is the only effective treatment present. T...
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34. MODE OF ACTION OF DROXINOSTAT
February 08, 2012
Histone deacetylases are the enzymes which work to transform the normal cells to tumor cells by activating different oncogenic pathways in the cells. Droxinostat is an inhibitor of these HDACs enzymes. Research studies have shown that the cancers can be control by modulating the activity of these HD...
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35. SNS-032 is another potent inhibitor of cyclin-dependent kinases
February 03, 2012
SNS-032 (BMS-387032) is really a selective cyclin-dependent kinase (CDK) inhibitor. Within this study, we examined its effects on primary acute myeloid leukemia (AML) samples (n=87). In vitro contact with SNS-032 for 48h led to an average LD(50) of 139±203nM Cytarabine (Ara-C) was a lot more than 35...
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36. Study of LY294002
February 03, 2012
Ly294002 is such an important PI3K inhibitor. Today, I would look back the classic article to review some information. The article “A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)” provides much important information.The article was...
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37. RAF265 INHIBITS RAF KINASE
February 02, 2012
In normal functioning of cells MAP kinase pathway plays a crucial role. When any factor changes this pathway to a hyperactive form, pathways like cellular growth, proliferation, survival and apoptosis are disturbed and it leads to the formation of tumor or cancer. Mitogen activated protein kinase (...
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38. MGCD0103 (MOCETINOSTAT)
February 02, 2012
Histone deacetylases are the enzymes which are responsible of deacetylating the histone proteins plays a key role in alternating the desired gene products. Many other proteins except histone proteins are also modulated in their expression by the Histone deacetylase enzymes or HDACs for example the p...
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39. Compound Libraries for Angiogenesis
February 02, 2012
Blood is transported in the body via blood vessels that form intercalated network of arteries, veins and capillaries. The normal process of growth and development of growth and development of new blood vessels form the pre-existing ones is called as angiogenesis. Angiogenesis is a normal process in ...
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40. SP600125 - CHECKS INFLAMMATORY DISORDERS, apoptosis inhibitor, LY294002
February 02, 2012
Being an inhibitor to JNK, SP600125 controls the stress activated response within the cells. Inflammatory diseases are generally the outcome of external stimuli like shock, bacterial endotoxin, hypoxia and UV radiation. During these diseases the immune proteins are expressed to a large extent. The e...
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Author: Calder Qimat
