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FISH technique is the most common method of HER2 breast cancer test by zhe mou
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FISH technique is the most common method of HER2 breast cancer test by ZHE MOU
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| Article Posted: 05/30/2011 |
| Article Views: 116 |
| Articles Written: 56 - MORE ARTICLES FROM THIS AUTHOR |
| Word Count: 426 |
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FISH technique is the most common method of HER2 breast cancer test |
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Blogs,Health,Writing
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HER2, belongs to the Epidermal Growth Factor receptor family, is one of The most vµlnerable oncogene in human tumor. Around 15 - 25% of women with early breast cancer hae a type called HER2-receptor positive disease. Breast carcinoma patients with positive expression of HER2 had higher metastatic rate(P<0.01) and poorer survival rate in 5 years(P<0.01). Fluorescence in situ hybridization (FISH) is the most common method of HER2 testing in the clinical. Fluorescence in situ hybridization (FISH) technique developed. The technique of hybridization in situ with fluorescence allowed him to identify new recurrent genetic changes that are involved in the appearance of this pathology. FISH technique operation difficult, Clinically, there are nearly 1 / 4 of the patients received inappropriate treatment as inaccurate test results. About 20% to 30% of breast cancer patients is HER2-positive breast cancer. Approximately 25 percent of women with breast cancer will have tumors that produce excessive amounts of HER2 protein. Over signals, stimulate cancer cell proliferation crazy. In breast cancer patient, her2 masculine breast cancer patient's worsened speed often is higher than the negative patient. Patients with HER2-positive breast cancer recurrence and distant metastasis is more likely compared to patients with other. Although HER2 positive breast cancer resistance to some chemotherapy, Biological targeted therapy is an effective treatment for HER2-positive breast cancer. Accurate HER2 testing of breast cancer play a decisive role for targeted therapy. Herceptin has demonstrated unprecedented efficacy in treating both early and advanced (metastatic) HER2 positive breast cancer. The mode of action of Herceptin is unique in that it activates the body's immune system and suppresses HER2 to target and destroy the tumour. If determined that her2 is a masculine gender, should in view of her2 gene marching song proper bead Shan Kangba to the treatment, reduce the recrudescence risk promptly. As research into HER2 therapies continues, similar techniques could be developed for other cancers over-expressing different proteins. Herceptin is currently being evaluated for treatment of HER2-positive stomach cancer through an extensive international clinical trial programme. All patients with breast cancer or gastric cancer and establish awareness of HER2 testing. EU and US Food and Drug Administration has approved HER2 targeted therapy used in patients with advanced gastric cancer in 2010. The results showed that patients with targeted treatment group extended the survival for 2.7 months, down 26% risk of death.breast cancer chemotherapy http://www.cancer-c.com is a new star of Cancer Rehabilitation Website it will be to provide the latest information about Traditional Chinese Medicine(TCM) Breast cancer treatment lung cancer mesothelioma Cancer Rehabilitation info
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