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Let me try to give you brief idea behind the over whelming demand of various molecules of the kinase family. These molecules are nothing else rather just a large number of enzymes regulating the intense kinds of activities of several proteins and more specifically other cellular activities of human body. Among the many other activities I define the addition of a phosphate group to a side chain of an amino acid is the major one. This is the most complicated regulatory mode among the other activities in the cellular sphere. Thus complicated action includes each phosphate group carrying two negative charges. The shape of the protein can be changed by an addition of one phosphate. Such a change in the shape of various protein molecules regulates the cellular activities. Kinase inhibitors are just the responsible factors in the process of such changes and additions in the phosphate groups in the human cells. Various members of this family are just responsible for several important activities in the intracellular signaling pathways. They are the responsible factors to turn on and turn off factors in the actions related with several cellular interchange. My study and research of such inhibitors instigate me to mention them as the controller of cell growth and various cell divisions. Among the others PDGFR inhibitor is the potential molecule of some activities as well. This is the basic criterion of some signal transudation pathways. They are the basic responsible factors in terms of tumor cell proliferation. They are the basic factors of various cell migration. Corneal neovascularization is the name of an unresolved problem in the medical therapy till today. Though a constant research has brought the serious importance of products like Tivozanib in the medical treatment process as far as this unresolved section is concerned. They are extremely important in the vessel formation and stabilization of this therapeutic problem. Even such products are extremely important to solve the several effective corneal angiogenesis. The PDGF inhibitors are the signaling pathways that result in the reduction process in the vessel density process in the unresolved therapeutic problem. They are the basic factors for the correlation of several reduced expressions of this process. These inhibitors are the stimulation factors of the PI3-K activation process, which has a special involvement in the regulatory mode of the whole system. It can be easily transformed by several decreased activation of the PI3-K signaling cascade. Angiogenesis is just another medical name of the new blood vessels coming from different preexisting capillaries. They are just some integral wings of the normal developmental procedure of numerous pathological instigations. Cornea is a major reason behind such an unresolved problem and infectious and inflammatory diseases, contact lens wear, trauma, chemical burn, and immunology diseases are the reason behind cornea. The treatment is not at all successful in various systems and through various developments altogether. Even the Laser treatment or photodynamic therapy can provide some temporary relief. Even some medical treatments a long with suppressing actively proliferating corneal vessels do not bring any such constant remedy of this problem. Though scientist are positive with the PI3-K activation process to bring the absolute solution. In a scientific terminology we may mention PDGFR as the functional peptide having a serious biologically active formation. The form of these inhibitors can influence several composition of receptor and this is the key factor in the developmental research of this problem. Such process can bring a significant effect on developing endothelial cells while promoting capillary maturation by a simple process of recruitment of various pericytes for growing vessels that is necessary for pericyte viability. We just hope by crossing our figures that this research can bring a huge success for the betterment of the mankind.
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Kinase inhibitors, PDGFR inhibitor, Tivozanib, PI3-K,
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