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Scholar-American invention of three-dimensional stem cell support - Support - Medical Devices Industry by big tree
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Scholar-American invention of three-dimensional stem cell support - Support - Medical Devices Industry by BIG TREE
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| Article Posted: 06/29/2010 |
| Article Views: 41 |
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Scholar-American invention of three-dimensional stem cell support - Support - Medical Devices Industry |
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Recently, Massachusetts Institute of Technology senior research fellow Shuguang Zhang and colleagues to the use of tiny protein fragments designed a new type of three-dimensional "scaffolding" in which stem cells can "scaffold" on growth, reproduction and differentiated into brain cells , and this "scaffolding" than any of the existing cell culture closer to the living body itself. The latest research published in the December 27, 2006 journal published online for free reading "Public Library of Science One" (PLoSOne) on.
Zhang Shuguang current MIT Biomedical Engineering Center deputy director. According to news reports PLoS Online, Zhang Shuguang said: "The reason why the special design support structure particularly interesting is that cells survive much longer, split better without additional soluble growth factor. This means extracellular microenvironment may function in cell survival and the achievement play a much larger role than before. "The study by the Olympus Corporation and the National Institutes of Health jointly funded.
1877, the German scientist Julius? Richard? Pightley invented for laboratory cultivation of bacteria such as small glass-covered pots?? Petri dish, it is bio-medical scientist who has been a classic weapons. But over time, biologists have increasingly felt the limitations of a Petri dish, because in a two-dimensional plane, cells, cell metabolism, gene expression and growth patterns have been distorted, but they can only choose glassware or the gel from mouse tumor protein mixtures?? basement membrane gel (Matrigel). Although the basement membrane extracellular glue and complex environment is similar, but it contains a number of growth factors and unknown proteins, limiting their experiments under precise application.
In the Life, the cells attached to the surrounding cells, tissues and proteins, and by their support. Cell's normal environment composed of tiny fibers, gaps and holes formed, oxygen, hormones and nutrients to pass, filter waste from the inside out. Cells if the stimulation by chemical substances, will move in this natural environment. So, can create a natural living environment similar to cell culture dish do?
Zhang Shuguang said in the paper: "30 years, scientists have been trying to Synthetic biopolymer microfiber scaffolds, which simulated three-dimensional micro-environment, but have been concerned about their degradation products." However, existing synthetic high Molecular biological material too, so that cells grow on them as the framework to force the spider in the skyscraper on the webs.
Zhang Shuguang trying to solve this problem, he and his colleagues have been working so-called self-assembly of small peptide fragments can form a useful amino acid structure. They invented a protein nanofibers formed by the support structure, in which each protein is a human hair fiber to 1 / 5000, support structure includes a needle hole in the 1 / 20000.
New nanofiber scaffold is the existing training system, 1 / 1000, the volume closer to self-replicating living cell extracellular matrix. And this support can be directly implanted into the body without side effects. Researchers have been able to grow in this three-dimensional scaffold healthy community adult mouse stem cells, and no two-dimensional training system defects.
This new synthetic structure not only provides an in vivo cell growth and behavior of the exact picture, to help researchers better understand the situation of cells in the body, but also for regenerative medicine and tissue cells in the tissue medium provides a more suitable micro-environment, such as skin grafts, damage to brain cells repair of neurons.
Due to increased activity of functional domains, called the modification of amino acid fragments of the stent structure can induce stem cell differentiation according to some expectations, for example, differentiate into a tissue or bone marrow or other natural destinations to mobile . Moreover, this activity of functional domains can be used for research into law the interaction between cells, cell migration, tumor and cancer cell interaction with normal cells, and cell-based drug testing and other applications. I am China Product writer, reports some information about diseqc motor , fet amplifier.
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