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Cialis prides itself as the product that can treat erectile dysfunction (ED) with the longest half-life. Generic Cialis, called Tadalafil, claims to be effective of up to 36 hours, and approximately 25 percent of the absorbed dose still remains in the body, thus having a 17 and a half hour half-life, as compared to the sildenafil, under the brand name Viagra, and vardenafil, under the name Levitra, which only have a four-hour half-life. Thus, Tadalafil or generic Cialis' action time is longer, earning it the moniker The Weekend Pill. The longer effectiveness of Tadalafil has also been made as grounds for a look into Tadalafil's use in the treatment of pulmonary arterial hypertension. Currently, the Viagra generic name sildenafil, marketed under the brand Revatio is approved in some parts of the world as a therapy for pulmonary arterial hypertension taken three times a day, which is only a fourth of Tadalafil's half-life. This leads experts to believe that generic Cialis, known as Tadalafil, would be more effective compared to the other two drugs. What makes the penis erect? When the penis is sexually stimulated, penile arteries and the corpus cavernosum's smooth muscle get relaxed, resulting in an increased flow of blood to the penis. This reaction happens alongside nerve terminals and endothelial cells releasing nitric oxide, which stimulates the formulation of Cyclic GMP in smooth muscle cells. Phosphodiesterase type 5 (PDE5) kicks in when it is inhibited. When PDE5 is inhibited, CSGMP is increased, thus enhancing the penis' erection. Compounds such as Tadalafil and sildenafil, among others, inhibit PDE5, but it should be coupled with sexual stimulation for nitric oxide to be produced. Thus, it is recommended that with sexual stimulation, men with erectile dysfunction take a 10 mg dose of Cialis. The dosage may be increased to as high as 20 mg or as low as 5 mg, depending on the patient's tolerance of the drug. To minimize the hassle of requiring a man to match his schedule of sexual activity and his schedule of using Cialis, low-dose Cialis have been approved by the European Commission and manufactured that can be consumed daily once a day as maintenance therapy for erectile dysfunction. Thus, 2.5 mg and 5 mg doses of Cialis are now available for daily dosages. As of the second quarter of 2009, Tadalafil has been approved in the United States as treatment for pulmonary arterial hypertension. Cialis as pulmonary arterial hypertension cure has pending marketing approval in other areas like Canada, Mexico, Japan, and the European Union. Men using Tadalafil complain of side effects such as a stuffy and running nose, headache, back pain, and flushing. The US FDA has also issued warnings for Tadalafil with infections including vision and hearing impairment. It should not be used with medications such as some alpha-blocker medication containing terazosin, and nitrates, as a combination of Tadalafil can have complications, including death. Also, do not take Tadalafil with other PDE5 inhibitors like ritonavir and antibiotic drugss like erythromycin for more than 10 mg as this may lead to overdose. For more information on Generic Cialis, visit Generic Cialis resource site.
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