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Researchers from the Bellvitge Biomedical Research Institute(IDIBELL) have identified the mechanism by which protein Zds1regulates a key function in mitosis, the process that occursimmediately before cell division. The result has been achieved inthe online edition of the Journal of Cell Science and opens the door to developing targeted and direct therapiesagainst cancer . In every organism, cells grow and divide into two daughter cellsthrough an orderly succession of events called "cell cycle". Cellshave to complete four main processes during the cell cycle: growth(G1 and G2 phases), doubling the DNA (S phase), segregation ofchromosomes (M phase, mitosis) and division (cytokinesis). In the Sphase or DNA replication, the genetic material is duplicated andthen during the M phase or mitosis, cells separate the duplicatedchromosomes between two daughter cells. This will ensure correctinheritance of genetic information from one cell generation to thenext. Chromosomal stability The transmission of genetic information (DNA) from parent to child(or equivalently, from cell to cell) is a fundamental question inbiology. Aneuploidy, ie lack or excess of chromosomes, is a featurepresent in almost all human cancers and promotes tumourdevelopment. Regulation of mitosis is particularly important formaintaining chromosomal stability. For example, tumour cells areaneuploid due to defects in the segregation of chromosomes, whichoriginate cells with more or less genetic material than usual. However, in spite of its importance, very little is known about theoutput regulation of mitosis. In the article published in theJournal of Cell Science, the Cell Cycle research group at IDIBELLled by Ethel Queralt, discovers a new mechanism of regulation ofmitotic exit. Separase protein is a key component for proper chromosomesegregation and the regulation of mitosis. In previous work, thegroup of Dr. Queralt described for the first time the involvementof Zds1 protein in mitosis. This protein cooperates with theseparase to ensure correct genetic inheritance from cell to cell. The study delves into the molecular mechanism by which this proteinZds1 regulates mitosis and contributes to the right segregation ofchromosomes. In this paper there have been used the yeast Saccharomyces cerevisiae as a model organism. Yeast is one of the most widely used model organisms to study basicprocesses in the cell, allowing to identify complex molecularmechanisms as the study of cell cycle in higher organisms. Theapplication of such basic knowledge will help to develop morespecific and direct treatments against various cancers. Dr. Queralt points out that "the mechanisms of regulation ofmitosis are very complex and well-known fact opens the door tospecific drugs that inhibit or enable to correct this process invarious diseases, especially cancer." She explains that mostanticancer drugs are being implemented without knowing exactly howthey work, "these are compounds that often we do not know how areworking, but they do. If we follow a reverse process, ie if westart to know the activity of a protein or part of the protein, wecould design specific drugs to minimize side effects." Dr.Queralt's researching is an important step in developing therapiesthat prevent tumour cells from replicating. Additional References Citations. I am an expert from healthy-ecigarette.com, while we provides the quality product, such as VAMO E Cig Manufacturer , ECAB E Cigarette Manufacturer, EVOD Electronic Cigarette,and more.
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