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"Severe Asthma With Fungal Sensitization In Children:Characterization Of A New Pediatric Asthma Sub-Phenotype" (SessionC27, Tuesday, May 22, 2012: 8:15-10:45 a.m., Room 2010-2012,Moscone Center; Abstract 28785) * Please note that numbers in this release may differ slightly fromthose in the abstract. Many of these investigations are ongoing;the release represents the most up-to-date data available at presstime. Abstract 28785 Severe Asthma With Fungal Sensitization In Children:Characterization Of A New Pediatric Asthma Sub-Phenotype Type: Scientific Abstract Category: 14.02 - Pediatric Asthma (PEDS) Authors: A.G. Vicencio1, E.A. Foley1, D. Bush1, K. Tsirilakis1,M.T. Santiago1, A. Stone2, D.L. Goldman3; 1Cohen Children's MedicalCenter - Great Neck, NY/US, 2Weill Cornell Medical College - NewYork, NY/US, 3Children's Hospital at Montefiore - Bronx, NY/US Abstract Body Rational: Severe asthma with fungal sensitization (SAFS) is a newlydescribed sub-phenotype of asthma which has been shown to respondto itraconazole therapy. Currently, the prevalence and clinicalcharacteristics for SAFS in children are unknown. Methods: We prospectively analyzed serum IgE levels and fungalsensitization patterns of children failing combination asthmatherapy in order to estimate the prevalence of SAFS in ourpopulation. We also compared clinical characteristics of SAFS andnon-SAFS patients. Results: Forty-one patients with asthma who were failing Step 4 orgreater therapy were recruited into the study. Of these patients,17 (41.5 %) were diagnosed with SAFS based on serum IgE and fungalsensitization testing. There was a male predominance in SAFScompared to non-SAFS patients, but this difference was notstatistically significant. Children with SAFS were older thannon-SAFS children (median ages 11 and 8.5 years, respectively,p=0.0325), and demonstrated higher serum IgE levels (more than 1log10 fold, Table 1). Children with SAFS also exhibited worsepulmonary function tests (PFTs), including FEV1, FEV1/FEV andFEF25-75 (Table 1). Differences in IgE and PFTs remainedsignificant when comparing SAFS children to a subset of thenon-SAFS children who were sensitized to non-fungal environmentalallergens. The most commonly implicated fungi (in decreasing order)included: Aspergillus spp (81.2%), Alternariaspp (68.8%), Candidaspp (31.2%), Cladosporiumspp (31.2%), Setomelanommaspp (31.2%),Mucorspp (25%) and Penicilliumspp (18.8%). More than 65% ofchildren with SAFS demonstrated sensitization to more than oneorganism. Conclusions: SAFS is a newly described sub-phenotype of asthma thatmay be under-diagnosed in children. Our results suggest that asignificant proportion of children failing Step 4 or greater asthmatherapy may have SAFS. Further characterization of SAFS in childrenis required to determine regional sensitization patterns, geneticand environmental risk factors, optimal treatment protocols andpreventive strategies. Funded by: None reported American Thoracic Society. I am an expert from cncprecision-machining.com, while we provides the quality product, such as China Mold Components , China Machined Plastic Parts, Precision Metal Stamping,and more.
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