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"Brain Injury And Cognitive Deficits Reverse With Treatment OfChildhood Obstructive Sleep Apnea" (Session A19, Sunday, May 20,10:15 a.m., Room 2020-2022, Moscone Center; Abstract 33865) * Please note that numbers in this release may differ slightly fromthose in the abstract. Many of these investigations are ongoing;the release represents the most up-to-date data available at presstime. Abstract 33865 Brain Injury And Cognitive Deficits Reverse With Treatment OfChildhood Obstructive Sleep Apnea Type: Late Breaking Abstract Category: 14.04 - Pediatric Sleep and Control of Breathing(PEDS/SRN) Authors: A.C. Halbower1, J. Janusz1, M. Brown2, J. Strain1, N.Friedman2, F. Accurso1, P.L. Smith3; 1Children's Hospital Coloradoand University of Colorado Denver - Aurora, CO/US, 2University ofColorado Denver - Aurora/US, 3Johns Hopkins University -Baltimore/US Abstract Body Introduction : To determine the reversibility of brain neuronalabnormalities with treatment of Pediatric Obstructive Sleep Apnea(OSA), OSA patients were compared to healthy controls (HC) matchedby age, gender, race, and SES. We hypothesized that neuronalalterations of the hippocampus and frontal cortex associated withchildhood sleep-disordered breathing would reverse with treatment. Methods : OSA patients (N=17) and healthy controls (N=11) age 8-11years, Tanner stage I-II, underwent neuropsychological testsspanning 7 domains. Magnetic resonance spectroscopy imaging of thebrain was performed in 15 OSA and 7 HC. OSA patients underwentAdenotonsillectomy followed by monitored CPAP if AHI 3, or nasaltreatments if AHI 2-3. Six months after treatment, 11 OSA patientsreturned for brain imaging and neuropsychological tests compared toHC. Results : Results: Children were mean age 10 yr, 55% male, 50%Hispanic, 20% AA. Mean OAHI for OSA patients = 13.6, for HC =0.3.Confirming our previous findings, N-acetyl aspartate to cholineratios (NAA/Cho) in the left hippocampus and left frontal cortexwere significantly decreased in OSA patients compared to HC (p=0.03and 0.04 respectively). OSA patients had a significant decrease inthe executive function of working memory (p= 0.00), attention(p=0.00) and verbal memory (p=0.02). After treatment, both left andright frontal cortex neuronal metabolites normalized (p= 0.03)while the hippocampal metabolites did not. Verbal memory improved(p=0.04) and improvements in attention were correlated with thenormalization of NAA/Cho in the frontal lobes (r=0.67, p=0.05). Conclusion: Conclusion: This is the first study demonstrating thatbrain metabolites of the neuronal network responsible for attentionand executive function, the frontal cortex, normalize withtreatment of pediatric OSA. Improvements in attention werecorrelated with the normalization of metabolites in the frontallobes. We speculate that earlier diagnosis and treatment ofchildhood OSA may improve the trajectory of development, thusimplying the need to identify these patients and expeditemanagement. Funded by: National Institutes of Health, National Center forResearch Resources American Thoracic Society. I am an expert from lipolaser-machines.com, while we provides the quality product, such as China Lipo Laser Machines , Diode Hair Removal Laser Manufacturer, Diode Hair Removal Laser,and more.
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