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Scientists have shed new light on how the phytosterol esters foundin products such as Flora pro.activ help lower blood cholesterol . A major clinical study has tracked the interaction of phytosterolesters with digestion and metabolism of cholesterol directly in theintestine and its subsequent levels in the blood after eating. The cholesterol-lowering effect of plant sterols has been knownsince the 1950s and repeatedly demonstrated in clinical trials.However, a recent study sponsored by Unilever, and in partnershipwith the French INSERM institute that conclusive proof that plantsterols esters markedly reduce free cholesterol availability in theintestine has been obtained. Previously, the precise mechanism bywhich plant sterol esters lower cholesterol was not fullyunderstood. The clinical study was carried out in Marseille, France andinvolved 12 male subjects. Each subject drank 500mL of liquid mealwhich contained deuterium enriched cholesterol and in the testproduct phytosterol esters. Samples were then taken at fixed timepoints from a tube in their small intestine and blood from theirarm. These samples were then analysed for their lipid composition.In-Vitro, experiments were also carried out to corroborate theclinical results. The results showed that plant sterol esters reduced the presence ofmeal-derived hepta-deuterated cholesterol in the circulation, andreduced the accumulation of cholesterol in the intestinal phase ofdigestion. This resulted in reduced cholesterol incorporation intomicelles and vesicles, hence less cholesterol was absorbed. The results have recently been published in the Journal of Lipid Research , and Guus Duchateau (Science leader Bioavailability & ADME*,Nutrition & Health) from Vlaardingen was one of the authors.Speaking about the research he said "To the best of our knowledgethis was one of the most invasive clinical trials ever carried outby Unilever R&D. It took a lot of preparation but what a success!Even now we are submitting a second, follow up paper from the samedata set". The World Health Organisation has estimated that 80% of coronary heart disease (CHD) and stroke cases could be prevented by implementing positive diet andlifestyle changes.1 Such changes include the uptake of a healthierdiet, increasing physical activity and cessation ofsmoking.Elevated LDL cholesterol is widely accepted as one of thekey modifiable risk factors associated with CHD.2 Wendy Duncan, Senior Nutrition & Health Nutrition Manager atUnilever says: "We have a long history of supporting scientificresearch into cholesterol and being at the forefront of itsmanagement through diet and lifestyle. This study was carried outas part of the ongoing support of science by Unilever. Ourscientists will continue to closely monitor developments incholesterol and plant sterol and stanol research, and will continueto progress our products and ranges accordingly." 1. World Health Organisation (WHO). WHO Technical Report Series916, Geneva, 2003 2. Tolonen H et al. Int J Epidemiol 2005; 34(1): 181-192 Source: Flora pro.activ Additional References Citations. I am an expert from mobilesecuritydvr.com, while we provides the quality product, such as Sd Mobile DVR , China SD PTZ Camera, Mobile Security DVR,and more.
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